Reengineered Epipodophyllotoxin

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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Detalles Bibliográficos
Autores principales: Magedov, Igor V., Evdokimov, Nikolai M., Karki, Menuka, Peretti, Amanda S., Lima, Dustin T., Frolova, Liliya, Reisenauer, Mary R., Romero, Anntherese E., Tongwa, Paul, Fonari, Alexandr, Altig, Jeff, Rogelj, Snezna, Antipin, Mikhail Yu., Shuster, Charles B., Kornienko, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563092/
https://ncbi.nlm.nih.gov/pubmed/22986348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc35044k
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