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Reengineered Epipodophyllotoxin
A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563092/ https://ncbi.nlm.nih.gov/pubmed/22986348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc35044k |
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