Reengineered Epipodophyllotoxin

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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Bibliographic Details
Main Authors: Magedov, Igor V., Evdokimov, Nikolai M., Karki, Menuka, Peretti, Amanda S., Lima, Dustin T., Frolova, Liliya, Reisenauer, Mary R., Romero, Anntherese E., Tongwa, Paul, Fonari, Alexandr, Altig, Jeff, Rogelj, Snezna, Antipin, Mikhail Yu., Shuster, Charles B., Kornienko, Alexander
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563092/
https://ncbi.nlm.nih.gov/pubmed/22986348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc35044k
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