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Reengineered Epipodophyllotoxin

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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Bibliografiske detaljer
Main Authors: Magedov, Igor V., Evdokimov, Nikolai M., Karki, Menuka, Peretti, Amanda S., Lima, Dustin T., Frolova, Liliya, Reisenauer, Mary R., Romero, Anntherese E., Tongwa, Paul, Fonari, Alexandr, Altig, Jeff, Rogelj, Snezna, Antipin, Mikhail Yu., Shuster, Charles B., Kornienko, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563092/
https://ncbi.nlm.nih.gov/pubmed/22986348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc35044k
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