Reengineered Epipodophyllotoxin

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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Detalhes bibliográficos
Main Authors: Magedov, Igor V., Evdokimov, Nikolai M., Karki, Menuka, Peretti, Amanda S., Lima, Dustin T., Frolova, Liliya, Reisenauer, Mary R., Romero, Anntherese E., Tongwa, Paul, Fonari, Alexandr, Altig, Jeff, Rogelj, Snezna, Antipin, Mikhail Yu., Shuster, Charles B., Kornienko, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563092/
https://ncbi.nlm.nih.gov/pubmed/22986348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc35044k
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