Chimeras of p14ARF and p16: Functional Hybrids with the Ability to Arrest Growth

The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line. This mutation aligns the reading frames of p14ARF and p...

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Detalhes bibliográficos
Principais autores: Williams, Richard T., Barnhill, Lisa M., Kuo, Huan-Hsien, Lin, Wen-Der, Batova, Ayse, Yu, Alice L., Diccianni, Mitchell B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914946/
https://ncbi.nlm.nih.gov/pubmed/24505435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088219
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