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Chimeras of p14ARF and p16: Functional Hybrids with the Ability to Arrest Growth
The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line. This mutation aligns the reading frames of p14ARF and p...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3914946/ https://ncbi.nlm.nih.gov/pubmed/24505435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088219 |
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