Frequent p16-Independent Inactivation of p14(ARF) in Human Melanoma

BACKGROUND: The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human melanoma, the accumulated evidence has suggested that the predominant tumor suppressor at 9p21 is p16, not ARF. However, recent obser...

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Опубликовано в: :J Natl Cancer Inst
Главные авторы: Freedberg, Daniel E., Rigas, Sushila H., Russak, Julie, Gai, Weiming, Kaplow, Margarita, Osman, Iman, Turner, Faye, Randerson-Moor, Juliette A., Houghton, Alan, Busam, Klaus, Bishop, D. Timothy, Bastian, Boris C., Newton-Bishop, Julia A., Polsky, David
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410798/
https://ncbi.nlm.nih.gov/pubmed/18505964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn157
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