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Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma

BACKGROUND: Enterohepatic recirculation of irinotecan and one of its metabolites, SN-38, has been observed in pharmacokinetic data sets from previous studies. A mathematical model that can incorporate this phenomenon was developed to describe the pharmacokinetics of irinotecan and its metabolites. P...

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Detalhes bibliográficos
Main Authors: Younis, Islam R., Malone, Samuel, Friedman, Henry S., Schaaf, Larry J., Petros, William P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914774/
https://ncbi.nlm.nih.gov/pubmed/18496691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0769-8
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