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Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats
BACKGROUND AND PURPOSE: Enterohepatic recirculation (EHC) is a common pharmacokinetic phenomenon that has been poorly modelled in animals. The presence of EHC leads to the appearance of multiple peaks in the concentration-time profile and increased exposure, which may have implications for drug effe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267282/ https://ncbi.nlm.nih.gov/pubmed/18193075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707643 |
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