Repeated H(2)O(2) exposure drives cell cycle progression in an in vitro model of ulcerative colitis

The production of hydrogen peroxide (H(2)O(2)) drives tumourigenesis in ulcerative colitis (UC). Recently, we showed that H(2)O(2) activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1). Moreover, caspases circumvented...

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Detalhes bibliográficos
Main Authors: Poehlmann, Angela, Reissig, Kathrin, Schönfeld, Peter, Walluscheck, Diana, Schinlauer, Antje, Hartig, Roland, Lessel, Wiebke, Guenther, Thomas, Silver, Andrew, Roessner, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914643/
https://ncbi.nlm.nih.gov/pubmed/24118792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12150
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