Repeated H(2)O(2) exposure drives cell cycle progression in an in vitro model of ulcerative colitis

The production of hydrogen peroxide (H(2)O(2)) drives tumourigenesis in ulcerative colitis (UC). Recently, we showed that H(2)O(2) activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1). Moreover, caspases circumvented...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Poehlmann, Angela, Reissig, Kathrin, Schönfeld, Peter, Walluscheck, Diana, Schinlauer, Antje, Hartig, Roland, Lessel, Wiebke, Guenther, Thomas, Silver, Andrew, Roessner, Albert
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons Ltd 2013
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914643/
https://ncbi.nlm.nih.gov/pubmed/24118792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12150
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