Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding

Dysregulation of c-Jun N-terminal kinase (JNK) activation promoted DNA damage response bypass and tumorigenesis in our model of hydrogen peroxide-associated ulcerative colitis (UC) and in patients with quiescent UC (QUC), UC-related dysplasia, and UC-related carcinoma (UC-CRC), thereby adapting to o...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Reissig, Kathrin, Silver, Andrew, Hartig, Roland, Schinlauer, Antje, Walluscheck, Diana, Guenther, Thomas, Siedentopf, Sandra, Ross, Jochen, Vo, Diep-Khanh, Roessner, Albert, Poehlmann-Nitsche, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478872/
https://ncbi.nlm.nih.gov/pubmed/28751935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9303158
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