Repeated H(2)O(2) exposure drives cell cycle progression in an in vitro model of ulcerative colitis

The production of hydrogen peroxide (H(2)O(2)) drives tumourigenesis in ulcerative colitis (UC). Recently, we showed that H(2)O(2) activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1). Moreover, caspases circumvented...

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Detaylı Bibliyografya
Asıl Yazarlar: Poehlmann, Angela, Reissig, Kathrin, Schönfeld, Peter, Walluscheck, Diana, Schinlauer, Antje, Hartig, Roland, Lessel, Wiebke, Guenther, Thomas, Silver, Andrew, Roessner, Albert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons Ltd 2013
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914643/
https://ncbi.nlm.nih.gov/pubmed/24118792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12150
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