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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor
[Image: see text] We report the synthesis of a GDP analogue, SML-8-73-1, and a prodrug derivative, SML-10-70-1, which are selective, direct-acting covalent inhibitors of the K-Ras G12C mutant relative to wild-type Ras. Biochemical and biophysical measurements suggest that modification of K-Ras with...
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Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2013
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3914205/ https://ncbi.nlm.nih.gov/pubmed/24259466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307387 |
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