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EZH2: biology, disease, and structure-based drug discovery

EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3. Overexpression of EZH2 has been found in a wide range of cancers, including those of the prostate and breast. In this review, we ad...

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Bibliographic Details
Main Authors: Tan, Jin-zhi, Yan, Yan, Wang, Xiao-xi, Jiang, Yi, Xu, H Eric
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914023/
https://ncbi.nlm.nih.gov/pubmed/24362326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.161
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