Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

Inflammatory hepatocellular adenomas (IHCAs) are benign liver lesions that can be characterized histologically by the presence of an inflammatory infiltrate and at the molecular level by the overexpression of acute phase inflammatory response genes. Recurrent somatic mutations of the interleukin-6 (...

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Bibliographic Details
Main Authors: Poussin, Karine, Pilati, Camilla, Couchy, Gabrielle, Calderaro, Julien, Bioulac-Sage, Paulette, Bacq, Yannick, Paradis, Valérie, Leteurtre, Emmanuelle, Sturm, Nathalie, Ramos, Jeanne, Guettier, Catherine, Bardier-Dupas, Armelle, Boulai, Anais, Wendum, Dominique, Selves, Janick, Izard, Tina, Nault, Jean-Charles, Zucman-Rossi, Jessica
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913689/
https://ncbi.nlm.nih.gov/pubmed/24501689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.27090
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