Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

Inflammatory hepatocellular adenomas (IHCAs) are benign liver lesions that can be characterized histologically by the presence of an inflammatory infiltrate and at the molecular level by the overexpression of acute phase inflammatory response genes. Recurrent somatic mutations of the interleukin-6 (...

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Dades bibliogràfiques
Autors principals: Poussin, Karine, Pilati, Camilla, Couchy, Gabrielle, Calderaro, Julien, Bioulac-Sage, Paulette, Bacq, Yannick, Paradis, Valérie, Leteurtre, Emmanuelle, Sturm, Nathalie, Ramos, Jeanne, Guettier, Catherine, Bardier-Dupas, Armelle, Boulai, Anais, Wendum, Dominique, Selves, Janick, Izard, Tina, Nault, Jean-Charles, Zucman-Rossi, Jessica
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913689/
https://ncbi.nlm.nih.gov/pubmed/24501689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.27090
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