Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

Inflammatory hepatocellular adenomas (IHCAs) are benign liver lesions that can be characterized histologically by the presence of an inflammatory infiltrate and at the molecular level by the overexpression of acute phase inflammatory response genes. Recurrent somatic mutations of the interleukin-6 (...

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Dettagli Bibliografici
Autori principali: Poussin, Karine, Pilati, Camilla, Couchy, Gabrielle, Calderaro, Julien, Bioulac-Sage, Paulette, Bacq, Yannick, Paradis, Valérie, Leteurtre, Emmanuelle, Sturm, Nathalie, Ramos, Jeanne, Guettier, Catherine, Bardier-Dupas, Armelle, Boulai, Anais, Wendum, Dominique, Selves, Janick, Izard, Tina, Nault, Jean-Charles, Zucman-Rossi, Jessica
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913689/
https://ncbi.nlm.nih.gov/pubmed/24501689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.27090
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