Loading...

Structural and Functional Analysis of G Protein–Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog

Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein–coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. Paroxetine exhibits up to 50-fold selectivity for GRK2 versus other GRKs. A better understanding of the molecular basis...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Homan, Kristoff T., Wu, Emily, Wilson, Michael W., Singh, Puja, Larsen, Scott D., Tesmer, John J. G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913355/
https://ncbi.nlm.nih.gov/pubmed/24220010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089631
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!