Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

G protein-coupled receptor kinase 2 (GRK2) is a well-established therapeutic target for the treatment of heart failure. Herein we identify the selective serotonin reuptake inhibitor (SSRI) paroxetine as a selective inhibitor of GRK2 activity both in vitro and in living cells. In the crystal structur...

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Autors principals: Thal, David M., Homan, Kristoff T., Chen, Jun, Wu, Emily K., Hinkle, Patricia M., Huang, Z. Maggie, Chuprun, J. Kurt, Song, Jianliang, Gao, Erhe, Cheung, Joseph Y., Sklar, Larry A., Koch, Walter J., Tesmer, John J.G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500392/
https://ncbi.nlm.nih.gov/pubmed/22882301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3003013
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