MG132 Ameliorates Kidney Lesions by Inhibiting the Degradation of Smad7 in Streptozotocin-Induced Diabetic Nephropathy

Background. Smad7 is the main negative regulatory protein in the transforming growth factor-β (TGF-β) downstream signaling pathway, which plays an important role in diabetic nephropathy (DN) and may be related to the ubiquitin proteasome pathway (UPP). Aim. We investigated the role of UPP in regulat...

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Detalhes bibliográficos
Main Authors: Gao, Chenlin, Aqie, Keri, Zhu, Jianhua, Chen, Guo, Xu, Ling, Jiang, Lan, Xu, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913347/
https://ncbi.nlm.nih.gov/pubmed/24511554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/918396
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