Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB

Our previous study showed that proteasomal inhibitor MG132 can prevent diabetic nephropathy (DN) along with upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). The present study was to investigate whether MG132 can prevent DN in wild-type and Nrf2-KO mice. Type 1 diabetes was induced...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Kong, Lili, Wang, Yangwei, Luo, Manyu, Tan, Yi, Cui, Wenpeng, Miao, Lining
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360973/
https://ncbi.nlm.nih.gov/pubmed/28373900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3671751
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