The Proteasome Inhibitor, MG132, Attenuates Diabetic Nephropathy by Inhibiting SnoN Degradation In Vivo and In Vitro

Transforming growth factor-β (TGF-β) has been shown to be involved in diabetic nephropathy (DN). The SnoN protein can regulate TGF-β signaling through interaction with Smad proteins. Recent studies have shown that SnoN is mainly degraded by the ubiquitin-proteasome pathway. However, the role of SnoN...

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Detalhes bibliográficos
Main Authors: Huang, Wei, Yang, Chen, Nan, Qinling, Gao, Chenlin, Feng, Hong, Gou, Fang, Chen, Guo, Zhang, Zhihong, Yan, Pijun, Peng, Juan, Xu, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070544/
https://ncbi.nlm.nih.gov/pubmed/25003128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/684765
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