A First-in-Class NAE Inhibitor, MLN4924, Blocks Lentiviral Infection in Myeloid Cells by Disrupting Neddylation-Dependent Vpx-Mediated SAMHD1 Degradation

MLN4924 is a first-in-class cancer drug that inhibits the Nedd8-activating enzyme (NAE). Herein, we report that MLN4924 inhibits Vpx/Vpr-induced SAMHD1 degradation by inhibiting the neddylation of E3 ubiquitin ligase and blocks macaque simian immunodeficiency virus (SIVmac) replication in myeloid ce...

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Bibliographische Detailangaben
Hauptverfasser: Wei, Wei, Guo, Haoran, Liu, Xianjun, Zhang, Hong, Qian, Lei, Luo, Kun, Markham, Richard B., Yu, Xiao-Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911698/
https://ncbi.nlm.nih.gov/pubmed/24155378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02568-13
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