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Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41
Induction of broadly neutralizing antibodies (bNAbs) is an important goal for HIV-1 vaccine development. Two autoreactive bNAbs, 2F5 and 4E10, recognize a conserved region on the HIV-1 envelope glycoprotein gp41 adjacent to the viral membrane known as the membrane-proximal external region (MPER). Th...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3911647/ https://ncbi.nlm.nih.gov/pubmed/24227838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02664-13 |
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