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Restraining the conformation of HIV-1 gp120 by removing a flexible loop
The trimeric HIV/SIV envelope glycoprotein, gp160, is cleaved to noncovalently associated fragments, gp120 and gp41. Binding of gp120 to viral receptors leads to large structural rearrangements in both fragments. The unliganded gp120 core has a disordered β3–β5 loop, which reconfigures upon CD4 bind...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1618118/ https://ncbi.nlm.nih.gov/pubmed/17006538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601358 |
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