Role of the Nuclease Activities Encoded by Herpes Simplex Virus 1 UL12 in Viral Replication and Neurovirulence

Enzyme-dead mutations in the herpes simplex virus 1 UL12 gene that abolished its endo- and exonuclease activities only slightly reduced viral replication in cell cultures. However, the UL12 null mutation significantly reduced viral replication, suggesting that a UL12 function(s) unrelated to its nuc...

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Main Authors: Fujii, Hikaru, Mugitani, Michio, Koyanagi, Naoto, Liu, Zhuoming, Tsuda, Shumpei, Arii, Jun, Kato, Akihisa, Kawaguchi, Yasushi
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
主題:
Genome Replication and Regulation of Viral Gene Expression
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911558/
https://ncbi.nlm.nih.gov/pubmed/24335305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03621-13
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