Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in the Intracellular Transport and Neurovirulence of Envelope Glycoprotein B

Herpes simplex virus 1 (HSV-1) Us3 protein kinase phosphorylates threonine at position 887 (Thr-887) in the cytoplasmic tail of envelope glycoprotein B (gB) in infected cells. This phosphorylation downregulates cell surface expression of gB and plays a role in viral pathogenesis in the mouse herpes...

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Bibliographic Details
Main Authors: Imai, Takahiko, Arii, Jun, Minowa, Atsuko, Kakimoto, Aya, Koyanagi, Naoto, Kato, Akihisa, Kawaguchi, Yasushi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126194/
https://ncbi.nlm.nih.gov/pubmed/21389132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02314-10
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