The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation

The herpes simplex virus 1 (HSV-1) UL12 protein (pUL12) is a nuclease that is critical for viral replication in vitro and neurovirulence in vivo. In this study, mass spectrometric analysis of pUL12 and phosphate-affinity SDS-polyacrylamide gel electrophoresis analysis identified tyrosine at pUL12 re...

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Detalhes bibliográficos
Main Authors: Fujii, Hikaru, Kato, Akihisa, Mugitani, Michio, Kashima, Yukie, Oyama, Masaaki, Kozuka-Hata, Hiroko, Arii, Jun, Kawaguchi, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178857/
https://ncbi.nlm.nih.gov/pubmed/24991005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01634-14
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