Rapid Detection of Mycobacterium tuberculosis and Pyrazinamide Susceptibility Related to pncA Mutations in Sputum Specimens through an Integrated Gene-to-Protein Function Approach

Testing the pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis isolates is challenging. In a previous paper, we described the development of a rapid colorimetric test for the PZA susceptibility of M. tuberculosis by a PCR-based in vitro-synthesized-pyrazinamidase (PZase) assay. Here, we...

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Main Authors: Li, Heng, Chen, Jun, Zhou, Man, Geng, Xuelei, Yu, Junping, Wang, Weihua, Zhang, Xian-En, Wei, Hongping
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911477/
https://ncbi.nlm.nih.gov/pubmed/24226918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02285-13
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