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TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation

Transforming growth factor β (TGF-β) inhibits myogenesis and associated gene expression. We previously reported that the TGF-β signaling effector Smad3 mediates this inhibition, by interfering with the assembly of myogenic bHLH transcription factor heterodimers on E-box sequences in the regulatory r...

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Udgivet i:EMBO J
Principais autores: Liu, Dong, Kang, Jong Seok, Derynck, Rik
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391082/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15044954/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600179
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