Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure to the H2 antagonists cimetidine and ranitidine. This effect appears to be H2 receptor-mediated as no change in receptor density was observed after H1 or H3 antagonist tre...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Smit, M J, Leurs, R, Alewijnse, A E, Blauw, J, Van Nieuw Amerongen, G P, Van De Vrede, Y, Roovers, E, Timmerman, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6802
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