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Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure to the H2 antagonists cimetidine and ranitidine. This effect appears to be H2 receptor-mediated as no change in receptor density was observed after H1 or H3 antagonist tre...

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Bibliografiske detaljer
Main Authors: Smit, M J, Leurs, R, Alewijnse, A E, Blauw, J, Van Nieuw Amerongen, G P, Van De Vrede, Y, Roovers, E, Timmerman, H
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC39108/
https://ncbi.nlm.nih.gov/pubmed/8692899
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