Cimetidine Does Not Inhibit 5-Aminolevulinic Acid Synthase or Heme Oxygenase Activity: Implications for Treatment of Acute Intermittent Porphyria and Erythropoietic Protoporphyria

Acute intermittent porphyria (AIP) is characterized by acute neurovisceral attacks that are precipitated by the induction of hepatic 5-aminolevulinic acid synthase 1 (ALAS1). In erythropoietic protoporphyria (EPP), sun exposure leads to skin photosensitivity due to the overproduction of photoreactiv...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Makiko Yasuda, Sangmi Lee, Lin Gan, Hector A. Bergonia, Robert J. Desnick, John D. Phillips
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-12-01
Schriftenreihe:	Biomolecules
Schlagworte:	porphyrias acute intermittent porphyria erythropoietic protoporphyria disorders of heme biosynthesis therapies for porphyrias cimetidine
Online-Zugang:	https://www.mdpi.com/2218-273X/14/1/27
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!