The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

Glial cell line-derived neurotrophic factor (GDNF) binds to the GDNF family co-receptor α1 (GFRα1) and activates RET receptor tyrosine kinase. GFRα1 has a putative domain structure of three homologous cysteine-rich domains, where domains 2 and 3 make up a central domain responsible for GDNF binding....

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Leppänen, Veli-Matti, Bespalov, Maxim M, Runeberg-Roos, Pia, Puurand, Ülo, Merits, Andres, Saarma, Mart, Goldman, Adrian
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2004
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15044950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600174
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