The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

Glial cell line-derived neurotrophic factor (GDNF) binds to the GDNF family co-receptor α1 (GFRα1) and activates RET receptor tyrosine kinase. GFRα1 has a putative domain structure of three homologous cysteine-rich domains, where domains 2 and 3 make up a central domain responsible for GDNF binding....

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Main Authors: Leppänen, Veli-Matti, Bespalov, Maxim M, Runeberg-Roos, Pia, Puurand, Ülo, Merits, Andres, Saarma, Mart, Goldman, Adrian
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC391078/
https://ncbi.nlm.nih.gov/pubmed/15044950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600174
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