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The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation
Glial cell line-derived neurotrophic factor (GDNF) binds to the GDNF family co-receptor α1 (GFRα1) and activates RET receptor tyrosine kinase. GFRα1 has a putative domain structure of three homologous cysteine-rich domains, where domains 2 and 3 make up a central domain responsible for GDNF binding....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC391078/ https://ncbi.nlm.nih.gov/pubmed/15044950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600174 |
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