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C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens

Apoptotic cells are a source of autoantigens and impairment of their removal contributes to the development of autoimmunity in C1q deficiency. However, the lack of complement component 3 (C3), the predominant complement opsonin, does not predispose to autoimmunity, suggesting a modifying role of C3...

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Main Authors: Baudino, Lucie, Sardini, Alessandro, Ruseva, Marieta M., Fossati-Jimack, Liliane, Cook, H. Terence, Scott, Diane, Simpson, Elizabeth, Botto, Marina
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910597/
https://ncbi.nlm.nih.gov/pubmed/24474777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316877111
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