Searching for missing heritability: Designing rare variant association studies

Genetic studies have revealed thousands of loci predisposing to hundreds of human diseases and traits, revealing important biological pathways and defining novel therapeutic hypotheses. However, the genes discovered to date typically explain less than half of the apparent heritability. Because effor...

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Библиографические подробности
Главные авторы: Zuk, Or, Schaffner, Stephen F., Samocha, Kaitlin, Do, Ron, Hechter, Eliana, Kathiresan, Sekar, Daly, Mark J., Neale, Benjamin M., Sunyaev, Shamil R., Lander, Eric S.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910587/
https://ncbi.nlm.nih.gov/pubmed/24443550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322563111
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