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Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

The alpha-factor pheromone receptor stimulates MATa yeast cells to undergo conjugation. The receptor contains seven transmembrane domains that function in ligand binding and in transducing a signal to the cytoplasmic receptor sequences to mediate G protein activation. A genetic screen was used to is...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Konopka, J B, Margarit, S M, Dube, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39101/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692892/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6764
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