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The Unfolded Protein Response Regulates Cardiac Sodium Current in Systolic Human Heart Failure
BACKGROUND: Human heart failure (HF) increases alternative mRNA splicing of the SCN5A cardiac Na(+) channel, generating variants encoding truncated, nonfunctional channels that are trapped in the endoplasmic reticulum. In this work, we tested whether truncated Na(+) channels activate the unfolded pr...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909518/ https://ncbi.nlm.nih.gov/pubmed/24036084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.000274 |
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