Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

BACKGROUND: Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water channel aquaporin-4 (AQP4). METHODS: Several app...

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Autori principali: Asavapanumas, Nithi, Ratelade, Julien, Papadopoulos, Marios C, Bennett, Jeffrey L, Levin, Marc H, Verkman, Alan S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909205/
https://ncbi.nlm.nih.gov/pubmed/24468108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-16
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