INVOLVEMENT OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN INFLAMMATORY DEMYELINATION IN A MOUSE MODEL OF NEUROMYELITIS OPTICA

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can cause paralysis and blindness. The pathogenesis of NMO involves binding of immunoglobulin G autoantibodies to aquaporin-4 (AQP4) on astrocytes, which is thought to cause complement-dependent cy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ratelade, Julien, Asavapanumas, Nithi, Ritchie, Alanna M., Wemlinger, Scott, Bennett, Jeffrey L., Verkman, A. S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890328/
https://ncbi.nlm.nih.gov/pubmed/23995423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1172-z
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