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INVOLVEMENT OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN INFLAMMATORY DEMYELINATION IN A MOUSE MODEL OF NEUROMYELITIS OPTICA
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can cause paralysis and blindness. The pathogenesis of NMO involves binding of immunoglobulin G autoantibodies to aquaporin-4 (AQP4) on astrocytes, which is thought to cause complement-dependent cy...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890328/ https://ncbi.nlm.nih.gov/pubmed/23995423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1172-z |
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