INVOLVEMENT OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN INFLAMMATORY DEMYELINATION IN A MOUSE MODEL OF NEUROMYELITIS OPTICA

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can cause paralysis and blindness. The pathogenesis of NMO involves binding of immunoglobulin G autoantibodies to aquaporin-4 (AQP4) on astrocytes, which is thought to cause complement-dependent cy...

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Hlavní autoři: Ratelade, Julien, Asavapanumas, Nithi, Ritchie, Alanna M., Wemlinger, Scott, Bennett, Jeffrey L., Verkman, A. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890328/
https://ncbi.nlm.nih.gov/pubmed/23995423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1172-z
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