INVOLVEMENT OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN INFLAMMATORY DEMYELINATION IN A MOUSE MODEL OF NEUROMYELITIS OPTICA

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can cause paralysis and blindness. The pathogenesis of NMO involves binding of immunoglobulin G autoantibodies to aquaporin-4 (AQP4) on astrocytes, which is thought to cause complement-dependent cy...

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Main Authors: Ratelade, Julien, Asavapanumas, Nithi, Ritchie, Alanna M., Wemlinger, Scott, Bennett, Jeffrey L., Verkman, A. S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890328/
https://ncbi.nlm.nih.gov/pubmed/23995423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1172-z
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