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Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss
The pathogenesis of neuromyelitis optica (NMO) involves targeting of NMO-immunoglobulin G (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system. Prior work provided evidence for complement-dependent cytotoxicity (CDC) in NMO lesion development. Here, we show that antibody-depen...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581313/ https://ncbi.nlm.nih.gov/pubmed/22526022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0986-4 |
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