Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

The pathogenesis of neuromyelitis optica (NMO) involves targeting of NMO-immunoglobulin G (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system. Prior work provided evidence for complement-dependent cytotoxicity (CDC) in NMO lesion development. Here, we show that antibody-depen...

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Bibliographic Details
Main Authors:	Ratelade, Julien, Zhang, Hua, Saadoun, Samira, Bennett, Jeffrey L., Papadopoulos, Marios C., Verkman, A. S.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3581313/ https://ncbi.nlm.nih.gov/pubmed/22526022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0986-4
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Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

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