Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes

BACKGROUND: Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this study was to assess the effect of genetic factors on EFV pharmacokinetics, treatment outcomes and genotype ba...

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Hlavní autoři: Mukonzo, Jackson K., Owen, Joel S., Ogwal-Okeng, Jasper, Kuteesa, Ronald B., Nanzigu, Sarah, Sewankambo, Nelson, Thabane, Lehana, Gustafsson, Lars L., Ross, Colin, Aklillu, Eleni
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909010/
https://ncbi.nlm.nih.gov/pubmed/24497997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086919
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