A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans

AIMS: Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, sex, demographic and biochemical variables on single-dose efavirenz pharmacok...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Mukonzo, Jackson K, Röshammar, Daniel, Waako, Paul, Andersson, Maria, Fukasawa, Takashi, Milani, Lili, Svensson, Jan Olof, Ogwal-Okeng, Jasper, Gustafsson, Lars L, Aklillu, Eleni
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Blackwell Science Inc 2009
विषय:
Pharmacokinetics
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791975/
https://ncbi.nlm.nih.gov/pubmed/19916993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03516.x
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