Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes

BACKGROUND: Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this study was to assess the effect of genetic factors on EFV pharmacokinetics, treatment outcomes and genotype ba...

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Main Authors: Mukonzo, Jackson K., Owen, Joel S., Ogwal-Okeng, Jasper, Kuteesa, Ronald B., Nanzigu, Sarah, Sewankambo, Nelson, Thabane, Lehana, Gustafsson, Lars L., Ross, Colin, Aklillu, Eleni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909010/
https://ncbi.nlm.nih.gov/pubmed/24497997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086919
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