Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Oncogenic K-ras mutations are frequently observed in colon cancers and contribute to transformed growth. Oncogenic K-ras is detected in aberrant crypt foci (ACF), precancerous colonic lesions, demonstrating that acquisition of a K-ras mutation is an early event in colon carcinogenesis. Here, we inve...

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Detalhes bibliográficos
Main Authors: Calcagno, Shelly R., Li, Shuhua, Colon, Migdalisel, Kreinest, Pamela A., Thompson, E. Aubrey, Fields, Alan P., Murray, Nicole R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908548/
https://ncbi.nlm.nih.gov/pubmed/18271008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23383
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