Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras(G12D) in the colonic epithelium stimulated hyperproliferat...

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Hauptverfasser: Haigis, Kevin M, Kendall, Krystle R, Wang, Yufang, Cheung, Ann, Haigis, Marcia C, Glickman, Jonathan N, Niwa-Kawakita, Michiko, Sweet-Cordero, Alejandro, Sebolt-Leopold, Judith, Shannon, Kevin M, Settleman, Jeffrey, Giovannini, Marco, Jacks, Tyler
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410301/
https://ncbi.nlm.nih.gov/pubmed/18372904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ngXXXX
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