Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras(G12D) in the colonic epithelium stimulated hyperproliferat...

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書誌詳細
主要な著者: Haigis, Kevin M, Kendall, Krystle R, Wang, Yufang, Cheung, Ann, Haigis, Marcia C, Glickman, Jonathan N, Niwa-Kawakita, Michiko, Sweet-Cordero, Alejandro, Sebolt-Leopold, Judith, Shannon, Kevin M, Settleman, Jeffrey, Giovannini, Marco, Jacks, Tyler
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410301/
https://ncbi.nlm.nih.gov/pubmed/18372904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ngXXXX
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