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Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo
Protein kinase C ι (PKCι) has been implicated in Ras signaling, however, a role for PKCι in oncogenic Ras-mediated transformation has not been established. Here, we show that PKCι is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Rockefeller University Press
2004
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172278/ https://ncbi.nlm.nih.gov/pubmed/15024028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200311011 |
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