Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by dysregulated proliferation of pulmonary artery smooth muscle cells leading to (mal)adaptive vascular remodeling. In the systemic circulation, vascular injury is associated with downregulation of sarcoplasmic reticulum Ca(2+)-ATPas...

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Main Authors: Hadri, Lahouaria, Kratlian, Razmig G., Benard, Ludovic, Maron, Bradley A., Dorfmüller, Peter, Ladage, Dennis, Guignabert, Christophe, Ishikawa, Kiyotake, Aguero, Jaume, Ibanez, Borja, Turnbull, Irene C., Kohlbrenner, Erik, Liang, Lifan, Zsebo, Krisztina, Humbert, Marc, Hulot, Jean-Sébastien, Kawase, Yoshiaki, Hajjar, Roger J., Leopold, Jane A.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908449/
https://ncbi.nlm.nih.gov/pubmed/23804254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.001585
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