Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells. MRP4/ABCC4 deficient mice display a reduction in smooth muscle cells proliferation and a prevention of pulmonary hypertension in response...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Claude, Caroline, Mougenot, Nathalie, Bechaux, Julia, Hadri, Lahouaria, Brockschnieder, Damian, Clergue, Michel, Atassi, Fabrice, Lompré, Anne-Marie, Hulot, Jean-Sébastien
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449024/
https://ncbi.nlm.nih.gov/pubmed/26052533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.65
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